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تاثیر ahcc بر روی باکتری کلبسیلا پنومونیه

KlebsiellapneumoniaInfections
 
Klebsiella pneumonia  is among  the most common  gram- negative bacteria healthcare providers encounter around the world. It is often found in hospitals, where it usually causes urinary tract infections, nosocomial pneumonia (pneumonia that develops as a result of treatment in a hospital or other healthcare setting) and intraabdominal infections. People most at risk for developing a  K.  pneumonia  infection  include  anyone  who  is  using  a  ventilator  or  who  has an intravenous catheter or patients who are on a prolonged course of antibiotics. Healthy individuals rarely get  Klebsiella  infections. Several  studies  have  looked  at  the  impact  of  AHCC  on  resistance to infection with  K. pneumonia  and the results have been promising. In one, published in the  Journal of Applied Physiology, investigators chose a mouse model that is often used for spaceflight conditions (e.g., suspension) because spaceflight conditions impair immune function.  The  scientists  administered  AHCC  to  the  mice  one  week before they were infected with  K. pneumonia  and were suspended and throughout the 10-day suspension period as well. Mice that received AHCC had decreased mortality, longer survival and an increased ability to clear the deadly bacteria from their bodies than
did control mice that did not receive AHCC. Another study evaluated how effective AHCC may be in preventing surgical wound infections caused by  K. pneumonia  in a  mouse  model.  The  28  treated mice  in  the  study  were  administered an oral  dose  of  AHCC  daily for eight days before and during the  time  they  were  infected  with K. pneumonia. A control group of  28  mice received  a  placebo  and were  also  infected  with  the  bacteria. The AHCC-treated mice survived  longer than  the  control mice:  15  percent  of  control  and 55 percent of treated mice were alive after 15 days. The AHCCtreated mice also cleared the infection much more effectively  than did the control mice. This suggests to scientists that AHCC  may  be  helpful  in  clearing  bacteria  in  patients  who  are  undergoing surgical procedures. The most recent study of the effect of AHCC on K. pneumonia was published in the  American Journal of Surgery. In the study, researchers found that AHCC-treated mice that were infected with the bacteria were able to clear the microorganisms entirely six days after they were infected. In addition, the investigators reported that levels of important  immune  system  cells—IL-12, IL-6 and TNF-a—peaked  earlier in  the AHCC  group than  they did  in the control group. These findings led them to conclude that AHCC appears to cause an early stimulation of the immune system, which leads to an effective clearance of the disease-causing bacteria and thus results in a more rapid recovery